Comprehensive Immunogenicity Solutions

Avantia Labs provide large molecule bioanalysis services to support the development of biotherapeutics, including cell and gene therapy from discovery research to preclinical and clinical development. With over 50% of our scientists holding advanced degrees (M.D./ Ph.D.) in biochemistry, molecular biology, cell biology, and immunology, our bioanalytical team is ready to work with you and to conquer any challenges you may encounter. We perform method development, method transfer, customization of commercial kits; method qualification and validation, finally sample analysis.

De-risk your biologic with Avantia Labs

MAPPs (MHC-II Associated Peptide Proteomics)

is an advanced immunogenicity assessment platform that identifies peptide sequences naturally processed and presented by MHC class II molecules on antigen-presenting cells (APCs). Unlike predictive in-silico models, MAPPs directly measures what the immune system “sees,” providing biologically relevant insights into potential T-cell epitopes. For our clients, this approach enables earlier, data-driven decisions during candidate selection—helping to design safer and more effective biologics or vaccines, reduce late-stage immunogenicity risks, and increase confidence in the drug’s safety profile.

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”The MAPPs assay helped us catch potential immune risks early, before we invested months in optimization. It’s the kind of clarity every R&D team needs.

Dr. Rachel NguyenSenior Scientist,

Additional Immunogenicity Assay Offerings

 

Our approaches to immunogenicity evaluation are to use the typical classical bridging assay and the atypical, less frequently used direct ligand binding assay, depending upon the available critical reagents and the drug modality.

Our evaluation package includes:

  • ADA (Anti-Drug Antibody) Assay
  • NAb (Neutralizing Antibody) Assay — includes:
    • Cell-based functional assay
    • Binding assay
  • Domain specificity assay
  • Isotype detection

A team of Immunogenicity Experts

🔬 Avantia Labs unites experienced scientists with over 10 years of expertise in large molecule bioanalysis and immunogenicity testing.

  • 🎓 Over half of our team hold M.D. or Ph.D. degrees in biochemistry,
    molecular biology, cell biology, or immunology.
  • ⚗️ We excel in method development, validation, and transfer across
    discovery to clinical studies.
  • 🤝 Our collaborative approach ensures reliable data and
    customized solutions for every biotherapeutic program.

Ready to Accelerate Your Biotherapeutic Program?

Contact Avantia Labs to discuss your assay development or immunogenicity testing needs.

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